❞ كتاب Combinatorial Library Methods and Protocols-Humana Press ❝ ⏤ Lisa Bellavance English

نبذه عن الكتاب:

Using a Noncovalent Protection Strategy
to Enhance Solid-Phase Synthesis
Fahad Al-Obeidi, John F. Okonya, Richard E. Austin,
and Dan R. S. Bond
1. Introduction
Since the introduction of solid-phase peptide synthesis by Merrifield (1)
nearly forty years ago, solid-phase techniques have been applied to the
construction of a variety of biopolymers and extended into the field of small
molecule synthesis. The last decade has seen the emergence of solid-phase
synthesis as the leading technique in the development and production of
combinatorial libraries of diverse compounds of varying sizes and properties.
Combinatorial libraries can be classified as biopolymer based (e.g., peptides,
peptidomimetics, polyureas, and others [2,3]) or small molecule based (e.g.,
heterocycles [4], natural product derivatives [5], and inorganic complexes
[6,7]). Libraries synthesized by solid-phase techniques mainly use polystyrenedivinylbenzene (PS) derived solid supports. Owing to physical and chemical
limitations of PS-derived resins, other resins have been developed (8,9). Most
of these resins are prepared from PS by functionalizing the resin beads with
oligomers to improve solvent compatibility and physical stability (8,9).
Solid-phase synthesis offers several attractive features over solution-phase
synthesis: (1) Molecules are synthesized while covalently linked to the solid support, facilitating the removal of excess reagents and solvents. (2) The solidsupported reaction can be driven to completion through the use of excess,
soluble reagents. (3) Mechanical losses are minimized as the compound–polymer
beads remain in single-reaction vessels throughout the synthesis. (4) Physical
manipulations are easy, rapid, and amenable to automation. (5) The physical
separation of the reaction centers on resin furnishes a “pseudo-dilution
Lisa Bellavance English - ❰ له مجموعة من الإنجازات والمؤلفات أبرزها ❞ Combinatorial Library Methods and Protocols-Humana Press ❝ ❱
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نبذة عن الكتاب:

Combinatorial Library Methods and Protocols-Humana Press

2002م - 1446هـ
نبذه عن الكتاب:

Using a Noncovalent Protection Strategy
to Enhance Solid-Phase Synthesis
Fahad Al-Obeidi, John F. Okonya, Richard E. Austin,
and Dan R. S. Bond
1. Introduction
Since the introduction of solid-phase peptide synthesis by Merrifield (1)
nearly forty years ago, solid-phase techniques have been applied to the
construction of a variety of biopolymers and extended into the field of small
molecule synthesis. The last decade has seen the emergence of solid-phase
synthesis as the leading technique in the development and production of
combinatorial libraries of diverse compounds of varying sizes and properties.
Combinatorial libraries can be classified as biopolymer based (e.g., peptides,
peptidomimetics, polyureas, and others [2,3]) or small molecule based (e.g.,
heterocycles [4], natural product derivatives [5], and inorganic complexes
[6,7]). Libraries synthesized by solid-phase techniques mainly use polystyrenedivinylbenzene (PS) derived solid supports. Owing to physical and chemical
limitations of PS-derived resins, other resins have been developed (8,9). Most
of these resins are prepared from PS by functionalizing the resin beads with
oligomers to improve solvent compatibility and physical stability (8,9).
Solid-phase synthesis offers several attractive features over solution-phase
synthesis: (1) Molecules are synthesized while covalently linked to the solid support, facilitating the removal of excess reagents and solvents. (2) The solidsupported reaction can be driven to completion through the use of excess,
soluble reagents. (3) Mechanical losses are minimized as the compound–polymer
beads remain in single-reaction vessels throughout the synthesis. (4) Physical
manipulations are easy, rapid, and amenable to automation. (5) The physical
separation of the reaction centers on resin furnishes a “pseudo-dilution . المزيد..

تعليقات القرّاء:

Biologically

Biology is a natural science that is concerned with the study of life, its various forms and its function, how these organisms interact with each other and with the surrounding environment. The word biology in Greek is made up of two words: bio (βίος) meaning life. And loggia (-λογία) means science or study. Biology: the similarity of vegetation and animal cover on the edges of the African and American states, and the existence of the same fossil.

Branches of biology
Biology is an ancient science thousands of years old and modern biology began in the nineteenth century. This science has multiple branches. Among them are:

Anatomy
Botany
Biochemia
Biogeography
Biofisia
Cytology or cell science
Ecology or environmental science

نبذه عن الكتاب:

Using a Noncovalent Protection Strategy
to Enhance Solid-Phase Synthesis
Fahad Al-Obeidi, John F. Okonya, Richard E. Austin,
and Dan R. S. Bond
1. Introduction
Since the introduction of solid-phase peptide synthesis by Merrifield (1)
nearly forty years ago, solid-phase techniques have been applied to the
construction of a variety of biopolymers and extended into the field of small
molecule synthesis. The last decade has seen the emergence of solid-phase
synthesis as the leading technique in the development and production of
combinatorial libraries of diverse compounds of varying sizes and properties.
Combinatorial libraries can be classified as biopolymer based (e.g., peptides,
peptidomimetics, polyureas, and others [2,3]) or small molecule based (e.g.,
heterocycles [4], natural product derivatives [5], and inorganic complexes
[6,7]). Libraries synthesized by solid-phase techniques mainly use polystyrenedivinylbenzene (PS) derived solid supports. Owing to physical and chemical
limitations of PS-derived resins, other resins have been developed (8,9). Most
of these resins are prepared from PS by functionalizing the resin beads with
oligomers to improve solvent compatibility and physical stability (8,9).
Solid-phase synthesis offers several attractive features over solution-phase
synthesis: (1) Molecules are synthesized while covalently linked to the solid support, facilitating the removal of excess reagents and solvents. (2) The solidsupported reaction can be driven to completion through the use of excess,
soluble reagents. (3) Mechanical losses are minimized as the compound–polymer
beads remain in single-reaction vessels throughout the synthesis. (4) Physical
manipulations are easy, rapid, and amenable to automation. (5) The physical
separation of the reaction centers on resin furnishes a “pseudo-dilution

Biology
Human biology
Who is the founder of biology?
The importance of biology
Areas of work in the field of biology
Theories of biology
Research on biology for the first grade of secondary school
Human biology

سنة النشر : 2002م / 1423هـ .
حجم الكتاب عند التحميل : 3.800 .
نوع الكتاب : pdf.
عداد القراءة: عدد قراءة Combinatorial Library Methods and Protocols-Humana Press

عدد قراءة Combinatorial Library Methods and Protocols-Humana Press

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Lisa Bellavance English -

❰ له مجموعة من الإنجازات والمؤلفات أبرزها ❞ Combinatorial Library Methods and Protocols-Humana Press ❝ ❱. المزيد..

كتب Lisa Bellavance English