❞ كتاب The BlooddBrain Barrier and Drug Delivery to the CNS ❝ ⏤ Michael Bradbury, David Begley, Jorg Kreuter

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Biology is a natural science that is concerned with the study of life, its various forms and its function, how these organisms interact with each other and with the surrounding environment. The word biology in Greek is made up of two words: bio (βίος) meaning life. And loggia (-λογία) means science or study. Biology: the similarity of vegetation and animal cover on the edges of the African and American states, and the existence of the same fossil.

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Biology is an ancient science thousands of years old and modern biology began in the nineteenth century. This science has multiple branches. Among them are:

Anatomy
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نبذه عن الكتاب:

Among the factors that influence uptake and distribution of a drug into a tissue
or organ outside the central nervous system (CNS) are blood flow, binding to
proteins in blood plasma, clearance from blood, and metabolism. Since capillaries in general have numerous water-filled channels across their walls which
allow ready escape of solutes up to the size of small proteins into interstitial
fluid, capillary permeability is not normally a factor in limiting drug uptake.
The contrary is true for brain and spinal cord. The blood–brain barrier (BBB)
is frequently a rate-limiting factor in determining permeation of a drug into
brain and is also an element in influencing steady state distribution. It is commonplace for pharmacologists and pharmaceutical chemists to make predictions concerning the pharmacological activity of a potential drug from its molecular structure. Those administering drugs active on cells of the CNS are
generally concerned to raise and maintain an optimum concentration of the
agent in the cerebral interstitial fluid where it is in contact with receptors. It
would be most helpful to be able to predict both permeability at the BBB and
steady state distribution of a potential neuropharmacological agent from its
molecular structure.

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